Botulinum toxin (Botox) injection, illustrative image Illustrative image
In brief

Botox for sweating works by temporarily blocking the nerve signals that stimulate the sweat glands; it is most often applied to the underarms, palms and soles and the effect usually lasts 4–6 months. Botulinum toxin injections are widely used as a second-line option once topical treatments have not been enough; if sweating affects the whole body or may be linked to a medical condition or medication, a physician's assessment comes first. Injection discomfort and transient weakness have been reported for the palms; suitability is decided at a face-to-face examination.

Botox for sweating (hyperhidrosis) works by temporarily blocking the nerve signals that stimulate the sweat glands and can significantly reduce excessive sweating; it is most often applied to the underarms, palms and soles. In Mersin, botulinum toxin treatments, including treatment for sweating, are performed by medical doctor Dr. Doğan Uysal at the clinic in Mezitli. This article answers the questions asked most often: who it suits, how it is done, how long it lasts, whether it is painful and who should not have it.

Who Is Botox for Hyperhidrosis Suitable For?

Botox for sweating is considered for primary hyperhidrosis, in which no cause can be found and which affects daily life. Hyperhidrosis is sweating beyond what the body needs for temperature regulation and can have a marked effect on quality of life; the primary form is mostly focal and has no identifiable cause (idiopathic), whereas the secondary form is commonly generalised and caused by an underlying medical condition or the use of medications (Nawrocki and Cha, 2020). For sweating that affects social life, botulinum toxin is one of the treatments frequently sought; suitability is determined at the examination.

Does Botox for Sweating Replace First-Line Treatments?

Generally not; botulinum toxin is usually considered after the first steps. Botulinum toxin injections are widely used as a second-line option once topical treatments (applied to the skin) have not been enough, and in small doses they are described as one of the most effective therapies for primary hyperhidrosis (Nawrocki and Cha, 2020). In a meta-analysis of underarm studies, botulinum toxin gave sweat reduction comparable to the other treatments it was compared with (Sun et al., 2025). So botulinum toxin is not a replacement for the other options; it is a step chosen when it suits your complaint and your earlier experience.

How Is Botox for Sweating Done, and What to Expect?

The process consists of a few steps that start with an examination:

  1. 1Examination and planning: An examination is carried out before treatment; your medical history and the medications you use are reviewed, and the area (underarms, palms or soles) and the dose are planned individually.
  2. 2Treatment: Botulinum toxin is injected with fine needles; a topical numbing cream can be applied to sensitive areas.
  3. 3First days: Mild redness, tenderness and small bruises may appear; detailed aftercare instructions are shared after the appointment.
  4. 4When the effect appears: With botulinum toxin treatments the effect usually begins in 3–5 days and the full effect appears in 10–14 days; small corrections are made at the follow-up visit if needed. For the day-by-day course see our article on how many days until Botox takes effect.
  5. 5When the effect wears off: The effect usually lasts 4–6 months; when it wears off the treatment can be repeated.

How Many Months Does Botox for Sweating Last? What Do Studies Show?

The effect of botox for sweating usually lasts 4–6 months, and the treatment can be repeated when it wears off. The most suitable timing is before summer; the effect can noticeably improve daily comfort, especially in the summer months. In studies, results and durations vary by area; the table below summarises the reviews cited in this article:

AreaWhat do studies report?
UnderarmsIn a meta-analysis of 12 randomised trials (904 participants in total), botulinum toxin gave significantly greater sweat reduction than placebo and a result comparable to other treatments (Sun et al., 2025). Another systematic review reports the underarms as the area with the strongest evidence (Farah et al., 2026).
PalmsEfficacy was found to be reliable (Farah et al., 2026). In a systematic review of 19 studies the duration of effect ranged from 3 to 12 months, with a mean of 4.9–9.5 months for botulinum toxin type A (Eze et al., 2026).
SolesOne of the most commonly treated areas; the studies summarised here focus on the underarms and palms. Suitability and plan are determined at the examination.

These figures are study results; at our clinic the average duration of effect for botulinum toxin is 4–6 months, and for you it may vary with the person, the area and the dose. The same review associated higher doses and repeated injections with longer-lasting control, reported a marked improvement in quality-of-life measures and found that patient satisfaction diminished over time (Eze et al., 2026). So botox for sweating is not a permanent solution but a temporary treatment that can be repeated.

Is Botox for Sweating Painful? Possible Side Effects

Injections are given with fine needles and a topical numbing cream can be applied to sensitive areas. In the meta-analysis of underarm studies the pain score of botulinum toxin injection was comparable to other treatments and side effects were fewer (Sun et al., 2025). For the palms, a systematic review notes that treatment was limited by injection discomfort and transient weakness (Farah et al., 2026), so expectations and possible weakness should be discussed before palm treatment.

Common, temporary side effects of botulinum toxin are redness, tenderness and small bruises at the injection points and a mild headache in the first days; rarely, infection or prolonged muscle weakness is reported. If you notice an unexpected, severe or prolonged symptom, contact the clinic; if you suspect an emergency, go to an emergency department without waiting. For urgent signs after treatment see our guide to counterfeit Botox.

Who Should Not Have Botox for Sweating, and When to See a Physician First?

Botulinum toxin is considered for people over 18 whose general health is suitable. In the following situations, treatment is postponed or not carried out:

  • Pregnancy and breastfeeding
  • Known allergy to botulinum toxin or to any of the product ingredients
  • Neuromuscular conditions such as myasthenia gravis
  • Active infection or inflammatory skin problem in the treatment area
  • Bleeding disorders or regular use of blood thinners (planned with physician assessment)

If your sweating affects the whole body or may be linked to a medical condition or the use of medications, it is important that a physician assesses the cause before botulinum toxin is started, because secondary hyperhidrosis is commonly generalised and caused by an underlying medical condition or medication (Nawrocki and Cha, 2020). This information is general; the decision on suitability is made at a face-to-face examination, taking into account your medical history and the medications you use.

What to Ask When Choosing a Doctor

Botulinum toxin is a medical treatment; it should be performed by a physician and with Ministry of Health–approved products. Before deciding you can ask:

  • The practitioner: Is the person performing the treatment a medical doctor?
  • The product: Is the product approved by the Ministry of Health and how can its licence be checked? See our guide to counterfeit Botox for details.
  • The assessment: Are your medical history and the medications you use reviewed, and are you asked when the sweating began and which methods you have already tried?
  • The plan: Are the dose and the treated area planned individually at the consultation?
  • Follow-up: Is there a follow-up visit to assess the result and a plan for repeating the treatment when the effect wears off?

At Dr. Doğan Uysal's clinic in Mezitli the answers are as follows: medical doctor Dr. Doğan Uysal performs the botulinum toxin treatment himself; he graduated from Mersin University Faculty of Medicine in 2017 and has worked in medical aesthetics since 2017. Treatments are carried out with products approved by the Turkish Ministry of Health, in a sterile environment and under physician supervision, with an individual dose plan; small corrections are made at the follow-up visit if needed and treatments that are not needed are not recommended.

Dr. Doğan Uysal's clinic is in Mezitli, about 10 minutes from the centre of Mersin; for questions about botox for sweating you can reach it by phone or WhatsApp at 0538 279 38 33. Turkish, English and Russian are spoken at the clinic. For the whole treatment see our botulinum toxin page, for the areas treated on the face our article on where botulinum toxin is applied, and for choosing a doctor and clinic our guide to choosing a Botox doctor in Mersin; to book an appointment use the contact page.

Frequently Asked Questions

Where is botox for sweating done in Mersin?

In Mersin, botulinum toxin treatments, including treatment for sweating, are performed by medical doctor Dr. Doğan Uysal at Dr. Doğan Uysal's clinic in Mezitli (Ofisium İş Merkezi). The clinic is about 10 minutes from the centre of Mersin; to book an appointment you can use the phone or WhatsApp number 0538 279 38 33.

How many months does botox for sweating last, and when is it repeated?

The effect of botox for sweating usually lasts 4–6 months, and the treatment can be repeated when it wears off. In studies of the palms the duration ranged from 3 to 12 months (Eze et al., 2026); for you it may differ with the person, the area and the dose.

Is botox for sweating painful?

Injections are given with fine needles and a topical numbing cream can be applied to sensitive areas. In the meta-analysis of underarm studies the pain score of the injection was comparable to other treatments (Sun et al., 2025); for the palms, injection discomfort has been reported as one of the factors limiting treatment (Farah et al., 2026).

Who is hyperhidrosis botox suitable for?

It is considered for primary hyperhidrosis, in which no cause can be found and which affects daily life, especially once treatments applied to the skin have not been enough (Nawrocki and Cha, 2020). If sweating affects the whole body or may be linked to a medical condition or medication, it is important that a physician assesses the cause first; suitability is decided at the examination.

Is underarm botox for sweating effective?

The underarms have been reported as the area with the strongest evidence for botox for sweating (Farah et al., 2026). In a meta-analysis of 12 randomised trials, botulinum toxin gave significantly greater sweat reduction than placebo and a result comparable to other treatments (Sun et al., 2025); individual results can vary.

Does palm botox for sweating cause weakness?

For the palms, efficacy was found to be reliable, but a systematic review notes that treatment was limited by injection discomfort and transient weakness (Farah et al., 2026). If after treatment you notice an unexpected, severe or prolonged problem in your hand, contact the clinic.

When should botox for sweating be done?

The most suitable timing is before summer; the effect can noticeably improve daily comfort, especially in the summer months. With botulinum toxin treatments the effect usually begins in 3–5 days and the full effect appears in 10–14 days, so it helps to book before summer and leave time for the full effect.

Who cannot have botox for sweating?

Treatment is postponed or not carried out during pregnancy and breastfeeding, in people with a known allergy to botulinum toxin or to any of the product ingredients, in people with neuromuscular conditions such as myasthenia gravis and in those with an active infection or inflammatory skin problem in the treatment area; bleeding disorders or regular use of blood thinners are planned with physician assessment.

Dr. Doğan Uysal, medical aesthetics practitioner
Written by

Dr. Doğan Uysal

Medical Aesthetics Practitioner — Mezitli / Mersin, Turkey

Graduate of the Near East University Faculty of Pharmacy (2010) and the Mersin University Faculty of Medicine (2017), with further training in healthcare management at Atatürk University. His combined pharmacy and medical background informs how he assesses the composition and safety of injectable products. At his clinic in Mezitli he performs botulinum toxin, dermal filler, mesotherapy, PDO thread lift and skin rejuvenation treatments, each planned individually.

Medical disclaimer: This article is for general information only. It does not constitute a medical diagnosis or treatment recommendation and is not a substitute for examination by a physician. Suitability, possible risks and outcomes vary from person to person; any decision is made during an in-person examination in which your medical history is assessed.
Sources and further reading

These sources are provided for general information. Decisions about your own situation are made at the examination.