Bioregeneration

Salmon DNA (PDRN) in Mersin

Support skin cell renewal with polynucleotide technology. An advanced biological therapy for elasticity, radiance and hydration balance.

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What Is Salmon DNA (PDRN)?

PDRN (polydeoxyribonucleotide) is a biological molecule derived from the sperm cells of salmon that shows a high degree of compatibility with human DNA. When injected into the skin it supports cellular renewal, promotes connective-tissue production and helps reduce inflammation.

In recent years, salmon DNA has become one of the most widely used bioregenerative treatments in Asia and Europe and can be a suitable option for people who want to work on overall skin quality in depth.

Who Is It Suitable For?

▸Skin that has lost elasticity or appears lax
▸A dull, tired or pale complexion
▸Fine lines and early signs of ageing
▸Under-eye dark circles and hollowness
▸Post-acne skin damage and scarring
▸Sun-damaged skin

Procedure and What to Expect

Salmon DNA injections are typically delivered in 3–4 sessions spaced 2–4 weeks apart. Each session lasts about 20–30 minutes; a topical anaesthetic cream is applied beforehand.

From the first session, many people notice increased hydration and radiance in the skin. The most pronounced results usually emerge 4–6 weeks after the programme is completed. The effect typically lasts 6–12 months and can be maintained with annual follow-up sessions. Results vary from person to person. Any treatment plan is subject to physician assessment.

Who Should Avoid Salmon DNA, and What Are the Possible Side Effects?

Salmon DNA (PDRN) is assessed on a case-by-case basis in people who are in good general health. In the following situations the procedure is postponed or not performed:

▸Pregnancy and breastfeeding
▸Known allergy to fish or seafood
▸Active infection, cold sores or open wounds in the treatment area
▸Bleeding disorders or regular use of blood thinners (planned only after physician assessment)
▸Uncontrolled chronic conditions and active autoimmune disease

Common and temporary side effects include redness at the injection sites, mild swelling, tenderness and small bruises; the redness usually subsides within 12–24 hours. Less commonly, small palpable bumps in the skin may last for a few days and prolonged oedema may occur. Rare effects include infection and allergic reaction. This is general information only; suitability and possible risks are discussed at an in-person consultation, taking into account personal health history and current medications. If you notice a symptom that is unexpected, severe or persistent, please contact the clinic.

The treatments described on this page are performed by Dr. Doğan Uysal, a medical doctor, at the clinic in Mezitli/Mersin. An in-person examination is carried out before treatment; suitability, possible risks and the plan are determined individually. To book an appointment please use the contact page.

Last reviewed: 19 September 2026

Frequently Asked Questions

Is salmon DNA safe?

Yes. PDRN molecules go through extensive biosafety testing and only approved products are used. Thanks to their high compatibility with human DNA, the risk of an allergic reaction is very low.

Can it be combined with botulinum toxin (Botox) or filler?

Yes. Salmon DNA can be combined with other medical aesthetic treatments. The most appropriate combination is planned during the consultation.

Are the results permanent?

Salmon DNA is not permanent, but it is a long-acting treatment. The effect typically lasts 6–12 months. Skin quality can be supported over the long term with annual maintenance sessions. Results vary from person to person.

When will I see the effect after the procedure?

Hydration and radiance begin to improve after the first session. The full effect usually becomes apparent about 4–6 weeks after a 3–4-session programme is completed.

What is salmon DNA (PDRN) therapy?

Salmon DNA therapy is a regenerative treatment in which polynucleotide (PDRN) molecules derived from salmon are injected into the skin. It supports cellular renewal, stimulates collagen synthesis and helps improve skin quality and elasticity.

What is the difference between salmon DNA and mesotherapy?

Mesotherapy delivers nourishing cocktails such as vitamins, minerals and hyaluronic acid to the skin. Salmon DNA specifically contains the PDRN molecule and targets tissue repair at the cellular level. The two are complementary; in some cases they are planned together.

How many sessions of salmon DNA therapy are needed?

The standard protocol is 3–4 sessions spaced 2–4 weeks apart. A maintenance session every six months is generally recommended. Dr. Doğan Uysal prepares an individual plan based on skin condition.

Is the salmon DNA treatment painful?

A topical anaesthetic cream is applied beforehand. Injections with fine needles may cause a slight stinging or burning sensation that passes quickly. Post-procedure redness usually subsides within 12–24 hours.

How long do the results of salmon DNA therapy last?

After a full course of sessions, benefits may last 6–12 months. Regular maintenance sessions help preserve the effect. Sun protection and a consistent skincare routine support longevity.

Where can I have salmon DNA therapy in Mersin?

You can visit Dr. Doğan Uysal's clinic in Mersin for salmon DNA (PDRN) therapy. The treatment is performed at the Mezitli clinic using approved PDRN products.

Who should not have salmon DNA therapy?

Salmon DNA is not applied in cases of active skin infection, pregnancy, breastfeeding, or a known allergy to fish or seafood. Individuals with autoimmune conditions require a physician assessment.

What is the difference between salmon DNA and a skin revitalisation injection?

A skin revitalisation injection (skin booster, commonly known in Turkey as gençlik aşısı) is hyaluronic acid-based and provides hydration and elasticity. Salmon DNA contains PDRN and supports cellular renewal. For tissue damage such as acne scars or under-eye darkening, salmon DNA can be a more targeted option.